We help molecular diagnostics developers select off-the-shelf or custom enzymes, optimise their use and address compatibility, concentration, volume and quantity requirements. From early R&D to larger-scale production, we manufacture critical raw materials in-house and supply enzymes and reagents at the concentrations and quantities required to support developing assays.
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Custom enzyme solutions
Support molecular diagnostic assay development through to commercial production
How LGC supports enzyme selection and supply
We connect enzyme selection and assay optimisation with a practical route towards larger-scale production and commercial supply.
Who we support
Molecular diagnostics developers, IVD manufacturers, assay development teams, research scientists and commercialisation teams seeking enzyme selection, optimisation, scale-up and supply support.
What they need
Custom enzymes, assay-specific formulations, compatibility testing, optimisation support, scalable supply options, bulk manufacturing and OEM solutions to support molecular diagnostic development and commercial production.
Explore related areas
Applications
Connect enzyme solutions with molecular diagnostic applications, from assay development and optimisation through to validation and commercial manufacturing.
Technologies
Explore amplification and nucleic acid analysis technologies that support molecular diagnostic workflows, assay performance and downstream data generation.
Featured Resources
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Why organisations choose LGC
Built around diagnostic assay success
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Global reach
144
Countries served worldwide
Locations
13
Sites supporting global operations
Frequently asked questions
Which polymerase suits my application?
Selection depends on your template, amplification method, assay chemistry, performance requirements and downstream workflow.
Do you support custom enzyme projects?
Yes. We help customers select an off-the-shelf or custom enzyme and optimise its use for the intended application.
Can you optimise enzyme concentration?
Yes. Support is available for enzyme concentrations, volumes, quantities and compatibility during assay development.
Can I evaluate an enzyme first?
Evaluation requests are available for selected enzyme technologies.
Do you offer bulk enzyme supply?
Selected enzymes are available in bulk configurations, with support extending from R&D development to larger-scale production.
Do you support OEM projects?
Bulk, custom and OEM enquiries are accepted for selected enzymes and reagents.
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Advance your assay with LGC
Discuss enzyme selection, custom formulations, optimisation and scalable supply with our technical team.
Choose your enzyme
Compare enzyme functions and workflow applications to identify an appropriate starting point for your assay development programme.
Enzyme and reagent comparison guide
Enzyme or Reagent Type | Primary Function | Relevant Applications | Selection Considerations |
|---|---|---|---|
Hot-start Taq DNA polymerase | Supports controlled DNA amplification | Endpoint PCR, qPCR and molecular diagnostic assays | Target type, specificity, assay chemistry and required quantity |
Thermostable reverse transcriptase | Produces first-strand cDNA from RNA templates | RT-PCR and RT-qPCR | RNA target, primer design and amplification workflow |
qPCR master mix | Combines essential amplification reagents in one formulation | qPCR, multiplex testing and diagnostic development | Assay format, primer and probe chemistry, workflow and scale |
Bst DNA polymerase | Supports amplification without conventional thermal cycling | Isothermal amplification | Amplification method, template and downstream application |
Phi29 DNA polymerase | Provides processive, high-fidelity DNA amplification | Limited or degraded DNA samples | Template quality, amplification method and intended output |
Thermostable DNA ligase | Joins adjacent DNA termini at elevated temperatures | Ligation-based detection and specialised workflows | Reaction temperature, stringency, format and concentration |
ssDNA ligase | Circularises single-stranded nucleic acid templates | Rolling-circle replication and transcription workflows | Template length, reaction design and project scale |
Thermostable RNase H | Degrades RNA within DNA:RNA hybrids | Hybrid selection and specialised diagnostic workflows | Reaction temperature, specificity and required quantity |