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Oligonucleotide Therapeutics Development and Manufacturing Solutions

Developing antisense oligonucleotide (ASO), siRNA and other oligonucleotide therapeutics requires reliable chemistry, scalable manufacturing materials and robust quality processes. LGC supports biotechnology organisations with phosphoramidites, solid supports, oligonucleotide synthesis capabilities and specialist expertise to help accelerate programmes from research through clinical development and commercial manufacture.

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Laboratory scientist using a pipette and test tube in a biotechnology research laboratory

Key challenges

Biotechnology developers face increasing pressure to scale programmes, maintain quality, ensure manufacturing consistency and meet regulatory expectations while progressing therapeutic oligonucleotides towards clinical use.

Scale-up

Transitioning from discovery-scale synthesis to larger production volumes without introducing variability or changing critical materials.

Impurity control

Managing impurity profiles and maintaining consistent product quality across development and manufacturing stages.

Process characterisation

Characterising product quality attributes, impurity profiles and manufacturing consistency to support oligonucleotide development and regulatory submissions.

Material supply

Securing reliable access to phosphoramidites, solid supports and synthesis components throughout programme lifecycles.

Regulatory readiness

Meeting documentation, quality and compliance requirements as programmes advance towards clinical applications.

Timeline pressure

Maintaining development momentum while balancing technical complexity, quality requirements and commercial milestones.

How LGC supports oligonucleotide therapeutics developers

Support for biotechnology organisations developing antisense oligonucleotide (ASO), siRNA and other oligonucleotide therapeutics from research through manufacturing and commercial readiness.

Who we support

Biotechnology companies, therapeutic developers, formulation scientists, process chemists and manufacturing teams working on oligonucleotide-based programmes and advanced molecular technologies.

How we help

We provide oligonucleotide synthesis materials, instrumentation, custom oligos and technical expertise to support development, scale-up, manufacturing readiness and commercial production.

Related applications

Supporting laboratory quality assurance and performance monitoring.

Support analytical accuracy and compliance

Lab Quality Control

Lab Quality Control

Explore solutions

Illustration of a single-stranded oligonucleotide molecule shown against a soft-focus scientific background.

Oligo Synthesis

Oligo Synthesizers

Instrument platforms supporting synthesis workflows.

Oligo Synthesizers

Related Products and Solutions

Biosearch Technologiesâ„¢

SKU: PRIMEMAX-001

PrimeMaxâ„¢ siRNA CPG

Optimised solid supports designed for the synthesis of siRNA.

PrimeMaxâ„¢ siRNA CPG

Biosearch Technologiesâ„¢

SKU: NACINS-007

MerMade 192X Oligo Synthesizer

High-throughput synthesis platform designed to support oligonucleotide screening and optimisation.

MerMade 192X Oligo Synthesizer

Biosearch Technologiesâ„¢

Custom Oligos

Custom oligonucleotide manufacturing services to support preclinical studies.

Custom Oligos

Biosearch Technologiesâ„¢

Large-Pore CPG Solid Supports

Solid support chemistries designed to accommodate longer and more complex therapeutic oligonucleotide sequences.

Large-Pore CPG Solid Supports

Why choose LGC for oligonucleotide therapeutics development

Supporting oligonucleotide therapeutics development with scalable manufacturing solutions and scientific expertise

Technical expertise

Extensive experience supporting advanced molecular workflows, oligonucleotide synthesis programmes and therapeutic development activities.

End-to-end support

Solutions spanning synthesis materials, instruments and custom oligos help streamline programme progression.

Trusted quality

Products and expertise designed to support consistency, reproducibility and confidence across research and development workflows.

Abstract scientific network representing a global community of experts supporting science and innovation.

Targeted Delivery of Nucleic Acid Therapeutics with Lipophilic Modifications 

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Employees

1,500+

Experts supporting global science

Products

11,000

Products supporting research, development and manufacturing workflows

Featured Resources

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NGS Assay Validation Guide

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Frequently asked questions

What programmes can LGC support?

LGC supports biotechnology organisations working in oligonucleotide synthesis, molecular biology, oligonucleotide chemistry, therapeutic development, synthesis scale-up and manufacturing workflows.

What therapeutic oligonucleotide applications can LGC support?

LGC supports the development and manufacture of antisense oligonucleotides (ASOs), siRNA, research oligos and other therapeutic oligonucleotide workflows through synthesis materials, instrumentation and custom manufacturing capabilities.

Do you support oligonucleotide manufacturing workflows?

Yes. LGC offers phosphoramidites, solid supports, oligo synthesizers and custom oligo capabilities supporting synthesis workflows.

Discuss your oligonucleotide therapeutics programme

Connect with specialists to explore solutions for oligonucleotide therapeutics development and manufacturing scale-up.

Contact us